منابع مشابه
Clinical roundtable monograph. New alternatives in CLL therapy: managing adverse events.
Chronic lymphocytic leukemia (CLL) is a B-cell leukemia mainly affecting older adults. Historically, CLL has been regarded as an incurable disease, and treatment has been confined to cytotoxic chemotherapy regimens. However, prognosis for patients treated with these agents remained poor, prompting the development of new, targeted agents. The introduction of rituximab, a CD20-targeted monoclonal...
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In this issue of Blood, Shanafelt and colleagues provide the first evidence that vitamin D deficiency is a risk factor for disease progression in chronic lymphocytic leukemia (CLL). Their findings imply that dietary vitamin D supplementation could potentially modify the natural history of this incurable disease.
متن کاملTelomere disrupts, CLL progresses.
In this issue of Blood, Lin and colleagues address in detail the nature and severity of telomere disruption in chronic lymphocytic leukemia (CLL).1 Using sophisticated methods for telomere length determination, the authors show that critical telomere shortening occurs in a proportion of CLL samples and correlates with the presence of large-scale genomic rearrangements occurring in telomeric reg...
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In this issue of Blood, Danese and colleagues present a large database analysis of patterns of care and outcomes with respect to chemoimmunotherapy for older patients with chronic lymphocytic leukemia (CLL). Their analysis demonstrates some of the important benefits and limitations of health services research as it relates to hematology.
متن کاملChronic lymphocytic leukaemia (CLL)
Typically, proliferation of mature small lymphocytes of normal morphology; lymphocytes with more abundant cytoplasm may be present. When prolymphocytes are 10% or greater they are classified as 'chronic lymphocytic leukaemia-prolymphocytic leukaemia'. The main immunophenotypic features that define BCLL are: the predominant population shares B-cell markers CD19, CD20, and CD23 with the CD5 antig...
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ژورنال
عنوان ژورنال: Info Onkologie
سال: 2015
ISSN: 1613-3633,2196-5692
DOI: 10.1007/s15004-015-0997-0